UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the Securities
Exchange Act of 1934
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☐ Preliminary Proxy Statement
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☐ Definitive Proxy Statement
☒ Definitive Additional Materials
☐ Soliciting Material Pursuant to §240.14a-12
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PLUS THERAPEUTICS, INC.
August 1, 2025
SUPPLEMENT TO THE PROXY STATEMENT
FOR THE ANNUAL MEETING OF SHAREHOLDERS
TO BE HELD ON AUGUST 7, 2025
EXPLANATORY NOTE
This supplement (the “Supplement”) to the definitive proxy statement filed by Plus Therapeutics, Inc. (the “Company”) with the Securities and Exchange Commission on July 21, 2025 (the “Proxy Statement”) relating to the
Company’s virtual annual meeting to be held at 9:00 AM, Eastern Time, on Thursday, August 7, 2025 (the “Annual Meeting”) is being filed solely to correct an inadvertent error with respect to the description of the voting standard for Proposal 3 – The
Reverse Stock Split Proposal (the “Reverse Stock Split Proposal”).
Except as specifically supplemented by the information contained below, all information set forth in the Proxy Statement remains unchanged.
The paragraph under the heading “Required Vote” on page 48 of the Proxy Statement, which states the voting standard applicable to the Reverse Stock Split Proposal, is revised to read as follows:
Required Vote
The affirmative vote of a majority of all votes cast by the holders of shares of Common Stock entitled to vote will be required for approval. Abstentions and broker non-votes, if any, will have no
effect on the outcome of this proposal.
The above correction has no effect on the treatment of abstentions and broker non-votes, if any, with respect to the Reverse Stock Split Proposal as described in the Proxy Statement, neither of which will have any
effect on the outcome of the proposal.
This Supplement does not change the proposals to be acted upon at the Annual Meeting, which are described in the Proxy Statement. If you have already voted your shares or submitted your proxy, you do not need to take
any action unless you wish to change your vote.