VOYA VARIABLE PORTFOLIOS, INC.

Voya Small Company Portfolio

(the "Portfolio")

Supplement dated July 29, 2022

to the Portfolio's Adviser Class, Class I, Class R6, and Class S Shares'

Prospectus, dated May 1, 2022, as supplemented

(the "Prospectus")

Effective July 12, 2022, Russell Shtern, CFA was added as a portfolio manager for the Portfolio.

Effective immediately, the Prospectus is revised as follows:

1.The sub-section of the Prospectus entitled "Portfolio Management – Portfolio Managers" in the Portfolio's Summary Section is deleted in its entirety and replaced with the following:

Portfolio Managers
Vincent Costa, CFA	Gareth Shepherd, PhD, CFA
Portfolio Manager (since 06/22)	Portfolio Manager (since 06/22)
Russell Shtern, CFA
Portfolio Manager (since 07/22)

2.The sub-section of the Prospectus entitled "Management of the Portfolios – The Sub-Advisers and Portfolio Managers – Voya Small Company Portfolio" is revised to add the following:

Russell Shtern, CFA, Portfolio Manager, joined Voya IM in July 2022. Previously Mr. Shtern served as a senior portfolio manager at Franklin Templeton's Investment Solutions group (2020-2022) where he was responsible for managing smart beta and active multi-factor equity strategies. Prior to Franklin Templeton, Mr. Shtern was head of equity portfolio management and trading and a member of the global equity management team for QS Investors (a Legg Mason affiliate), a quantitative multi-asset and equity manager (2014-2020).

PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE

VOYA VARIABLE PORTFOLIOS, INC.

Voya Small Company Portfolio

(the "Portfolio")

Supplement dated July 29, 2022

to the Portfolio's Adviser Class, Class I, Class R6, and Class S Shares'

Statement of Additional Information, dated May 1, 2022, as supplemented

(the "SAI")

Effective July 12, 2022, Russell Shtern, CFA was added as a portfolio manager for the Portfolio.

Effective immediately, the SAI is revised as follows:

1.The table in the sub-section of the SAI entitled "Sub-Adviser – Portfolio Management – Other Accounts Managed" is amended to include the following:

	Registered Investment		Other Pooled		Other Accounts
	Companies		Investment Vehicles
	Number of	Total	Number of	Total	Number of	Total
Portfolio Manager	Accounts	Assets	Accounts	Assets	Accounts	Assets
Russell Shtern, CFA4	0	$0	0	$0	0	$0

4As of May 31, 2022.

2.The line item with respect to the Portfolio in the table in the sub-section of the SAI entitled "Sub- Adviser – Portfolio Management – Compensation" is deleted in its entirety and replaced with the following:

Fund	Portfolio Manager	Benchmark
Voya Small Company Fund	Vincent Costa, CFA,	Russell 2000® Index
	Gareth Shepherd, PhD, CFA, and
	Russell Shtern, CFA

3.The table in the sub-section of the SAI entitled "Sub-Adviser – Portfolio Management – Ownership of Securities – Voya Small Company Portfolio" is amended to include the following:

Portfolio Manager	Dollar Range of Fund Shares Owned
Russell Shtern, CFA2	None

2As of May 31, 2022.

PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE