NEW
RIVER PHARMACEUTICALS INC.
|
(Name
of Issuer)
|
Common
Stock
|
(Title
of Class of Securities)
|
648468
20 5
|
(CUSIP
Number)
|
Third
Security, LLC
1881
Grove Avenue
Radford,
Virginia 24141
Attention:
Marcus E. Smith, Esq.
(540)
633-7978
|
(Name,
Address and Telephone Number of Person
Authorized
to Receive Notices and Communications)
|
Copy
to:
David
I. Meyers, Esq.
John
Owen Gwathmey, Esq.
Troutman
Sanders LLP
Troutman
Sanders Building
1001
Haxall Point
Richmond,
Virginia 23219
(804)
697-1239
|
February
20, 2007
|
(Date
of Event which Requires Filing of this
Statement)
|
CUSIP
No. 648468 20 5
|
|
Page 2
of
9
|
1
|
NAME
OF REPORTING PERSONS
I.R.S.
IDENTIFICATION NOS. OF ABOVE PERSONS
Randal
J. Kirk
|
|
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF GROUP
Yes
(a) o
No
(b) x
|
|
3
|
SEC
USE ONLY
|
|
4
|
SOURCE
OF FUNDS
PF
|
|
5
|
CHECK
IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
PURSUANT
TO ITEM 2(d) OR 2(e) £
|
|
6 |
CITIZENSHIP
OR PLACE OF ORGANIZATION
United
States
|
|
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE
VOTING POWER
2,278,668
|
8
|
SHARED
VOTING POWER
16,331,748
|
|
9
|
SOLE
DISPOSITIVE POWER
2,278,668
|
|
10
|
SHARED
DISPOSITIVE POWER
16,331,748
|
|
11
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
18,610,416
|
|
12
|
CHECK
IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
CERTAIN SHARES £ |
|
13
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
50.2% |
|
14
|
TYPE
OF REPORTING PERSON
IN |
CUSIP
No. 648468 20 5
|
|
Page 3
of
9
|
1
|
NAME
OF REPORTING PERSONS
I.R.S.
IDENTIFICATION NOS. OF ABOVE PERSONS
RJK,
L.L.C.
I.R.S.
IDENTIFICATION NO.: 54-1816015
|
|
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF GROUP
Yes
(a) o
No
(b) x
|
|
3
|
SEC
USE ONLY
|
|
4
|
SOURCE
OF FUNDS
WC
|
|
5
|
CHECK
IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
PURSUANT
TO ITEM 2(d) OR 2(e) £
|
|
6 |
CITIZENSHIP
OR PLACE OF ORGANIZATION
Virginia
|
|
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE
VOTING POWER
0
|
8
|
SHARED
VOTING POWER
5,764,637
|
|
9
|
SOLE
DISPOSITIVE POWER
0
|
|
10
|
SHARED
DISPOSITIVE POWER
5,764,637
|
|
11
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
5,764,637
|
|
12
|
CHECK
IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
CERTAIN SHARES £ |
|
13
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
15.6%
|
|
14
|
TYPE
OF REPORTING PERSON
OO
- limited liability
company
|
CUSIP
No. 648468 20 5
|
|
Page 4
of
9
|
1
|
NAME
OF REPORTING PERSONS
I.R.S.
IDENTIFICATION NOS. OF ABOVE PERSONS
New
River Management II, LP
I.R.S.
Identification No.: 65-1166473
|
|
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF GROUP
Yes
(a) o
No
(b) x
|
|
3
|
SEC
USE ONLY
|
|
4
|
SOURCE
OF FUNDS
WC
|
|
5
|
CHECK
IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
PURSUANT
TO ITEM 2(d) OR 2(e) £
|
|
6 |
CITIZENSHIP
OR PLACE OF ORGANIZATION
Virginia
|
|
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE
VOTING POWER
0
|
8
|
SHARED
VOTING POWER
4,415,278
|
|
9
|
SOLE
DISPOSITIVE POWER
0
|
|
10
|
SHARED
DISPOSITIVE POWER
4,415,278
|
|
11
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
4,415,278
|
|
12
|
CHECK
IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
CERTAIN SHARES £ |
|
13
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11.9%
|
|
14
|
TYPE
OF REPORTING PERSON
PN
|
CUSIP
No. 648468 20 5
|
|
Page 5
of
9
|
Item
1.
|
Security
and Issuer.
|
Item
2.
|
Identity
and Background.
|
Source
and Amount of Funds or Other Consideration.
|
CUSIP
No. 648468 20 5
|
|
Page 6
of
9
|
Item
4.
|
Purpose
of Transaction.
|
CUSIP
No. 648468 20 5
|
|
Page 7
of
9
|
Item 5. |
Interest
in Securities of the Issuer.
|
(i) |
sole
power to vote or to direct the vote -
2,278,668
|
(ii) |
shared
power to vote or to direct the vote - 16,331,748(1)
|
(iii) |
sole
power to dispose of or to direct the disposition of -
2,278,668
|
(iv) |
shared
power to dispose of or to direct the disposition of 16,331,748(1)
|
CUSIP
No. 648468 20 5
|
|
Page 8
of
9
|
Item
6.
|
Contracts,
Arrangements, Understandings or Relationships with Respect to Securities
of the Issuer.
|
Item
7.
|
Material
to be Filed as Exhibits.
|
Exhibit
1
|
Agreement
and Plan of Merger, dated as of February 20, 2007, by and among Shire
plc,
Shuttle Corporation and New River Pharmaceuticals Inc., including
the form
of Tender and Support Agreement, dated as of February 20, 2007, by
and
among Shire plc, Randal J. Kirk, Kirkfield, L.L.C., New River Management
II, LP, New River Management III, LP, RJK, L.L.C., Third Security
Staff
2001 LLC, Randal J. Kirk (2000) Limited Partnership, Trust under
R.J. Kirk
Declaration of Trust, dated March 29, 2000, between Randal J. Kirk,
as
settlor, and Randal J. Kirk, as trustee, and Lotus Capital (2000)
Company
Inc. as Exhibit A and the Plan of Merger as Exhibit B thereto (filed
as
Exhibit 2.1 to the Current Report on Form 8-K, dated as of February
20,
2007, and incorporated herein by
reference).
|
Exhibit
2
|
Tender
and Support Agreement, dated as of February 20, 2007, by and among
Shire
plc, Randal J. Kirk, Kirkfield, L.L.C., New River Management II,
LP, New
River Management III, LP, RJK, L.L.C., Third Security Staff 2001
LLC,
Randal J. Kirk (2000) Limited Partnership, Trust under R.J. Kirk
Declaration of Trust, dated March 29, 2000, between Randal J. Kirk,
as
settlor, and Randal J. Kirk, as trustee, and Lotus Capital (2000)
Company
Inc.
|
Exhibit
3
|
Joint
Filing Agreement, dated as of February 14, 2007, by and among Randal
J.
Kirk, RJK, L.L.C. and New River Management II,
LP
|
CUSIP
No. 648468 20 5
|
|
Page 9
of
9
|
/s/ Randal J. Kirk | ||
Randal J. Kirk | ||
RJK, L.L.C. | ||
By:
|
/s/
Randal J. Kirk
|
|
Randal
J. Kirk
|
||
Manager
|
||
NEW RIVER MANAGEMENT II, LP | ||
By:
|
Third
Security Capital Partners, LLC,
|
|
its
General Partner
|
||
By:
|
Third
Security, LLC,
|
|
its
Managing Member
|
||
By:
|
/s/
Randal J. Kirk
|
|
Randal
J. Kirk
|
||
Manager
|
Exhibit
1
|
Agreement
and Plan of Merger, dated as of February 20, 2007, by and among Shire
plc,
Shuttle Corporation and New River Pharmaceuticals Inc., including
the form
of Tender and Support Agreement, dated as of February 20, 2007, by
and
among Shire plc, Randal J. Kirk, Kirkfield, L.L.C., New River Management
II, LP, New River Management III, LP, RJK, L.L.C., Third Security
Staff
2001 LLC, Randal J. Kirk (2000) Limited Partnership, Trust under
R.J. Kirk
Declaration of Trust, dated March 29, 2000, between Randal J. Kirk,
as
settlor, and Randal J. Kirk, as trustee, and Lotus Capital (2000)
Company
Inc. as Exhibit A and the Plan of Merger as Exhibit B thereto (filed
as
Exhibit 2.1 to the Current Report on Form 8-K, dated as of February
20,
2007, and incorporated herein by
reference).
|
Tender
and Support Agreement, dated as of February 20, 2007, by and among
Shire
plc, Randal J. Kirk, Kirkfield, L.L.C., New River Management II,
LP, New
River Management III, LP, RJK, L.L.C., Third Security Staff 2001
LLC,
Randal J. Kirk (2000) Limited Partnership, Trust under R.J. Kirk
Declaration of Trust, dated March 29, 2000, between Randal J. Kirk,
as
settlor, and Randal J. Kirk, as trustee, and Lotus Capital (2000)
Company
Inc.
|
Joint
Filing Agreement, dated as of February 14, 2007, by and among Randal
J.
Kirk, RJK, L.L.C. and New River Management II,
LP
|